What is the weight-based dosing for Tenecteplase in acute ischemic stroke?

What is the weight-based dosing for Tenecteplase in acute ischemic stroke?

• A. 0.25 mg/kg with a maximum of 25 mg
• B. 0.4 mg/kg
• C. 0.75 mg/kg
• D. 1 mg/kg

Answer: (A)

In acute ischemic stroke, tenecteplase is given as a single IV bolus dosed by body weight at 0.25 mg/kg, with a maximum total dose of 25 mg. This approach provides enough thrombolytic effect to help dissolve the clot while keeping the risk of intracranial hemorrhage in check, and the 25 mg cap prevents overdose in heavier patients. Higher weight-based doses, such as 0.4 mg/kg, 0.75 mg/kg, or 1 mg/kg, have not shown added benefit in stroke and carry greater bleeding risk, so they are not used for this indication.

In acute ischemic stroke, tenecteplase is given as a single IV bolus dosed by body weight at 0.25 mg/kg, with a maximum total dose of 25 mg. This approach provides enough thrombolytic effect to help dissolve the clot while keeping the risk of intracranial hemorrhage in check, and the 25 mg cap prevents overdose in heavier patients. Higher weight-based doses, such as 0.4 mg/kg, 0.75 mg/kg, or 1 mg/kg, have not shown added benefit in stroke and carry greater bleeding risk, so they are not used for this indication.